Search results for " ANTITUBULIN AGENTS"

showing 2 items of 2 documents

Synthesis of the new ring system pyrrolizino[2,3-b]indol-4(5H)-one

2011

Derivatives of the new ring system pyrrolizino[2,3-b]indol-4(5H)-one were prepared in four steps starting from substituted benzonitriles bearing a functionalized amino group in the adjacent position. The unsubstituted- and the dimethoxy-pyrrolizinoindolones 5a and 5b exhibited modest activity against the HL-60(TB) human leukemia cell line, whereas the N-methylated dimethoxy-pyrrolizinoindolone 6b showed to be selective against MOLT-4 leukemia, A549/ATCC, HOP-92, and NCI-H460 non-small cell lung cancer, and CAKI-1 renal cancer cell lines.

NitrileStereochemistryOrganic ChemistryCancerBiological activityRing (chemistry)medicine.diseaseSettore CHIM/08 - Chimica FarmaceuticaBiochemistryChemical synthesisPyrrolizino[2; 3-b]indol-4(5H)-one Tripentone Antitumor activity Antitubulin agentsPyrrolizino[23-b]indol-4(5H)-one Tripentone Antitumor activity Antitubulin agentschemistry.chemical_compoundLeukemia3-b]indol-4(5H)-one Tripentone Antitumor activity Antitubulin agentschemistryCell cultureDrug DiscoveryPyrrolizino[2medicineSelectivity
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SYNTHESIS OF NEW RING SYSTEMS PYRROLIZINES AS POTENTIAL ANTITUBULIN AGENTS

PYRROLIZINES ANTITUBULIN AGENTS ANTICANCERSettore CHIM/08 - Chimica Farmaceutica
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